FMoc-2-aMinoisobutyric acid FMoc-α-Methylalanine
fmoc-alpha-methylalanine
CAS: 94744-50-0
Molecular Formula: C19H19NO4
FMoc-2-aMinoisobutyric acid FMoc-α-Methylalanine - Names and Identifiers
| Name | fmoc-alpha-methylalanine |
| Synonyms | Fmoc-Aib-OH Fmoc-alpha-Me-Ala-OH fmoc-alpha-methylalanine Fmoc-2-aminoisobutyric acid N-FMOC-C-ALPHA-METHYLALANINE N-ALPHA-FMOC-ALPHA-AMINOISOBUTYRIC ACID N-ALPHA-FMOC-L-ALPHA-AMINOISOBUTYRIC ACID FMoc-2-aMinoisobutyric acid FMoc-α-Methylalanine N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-ALPHA-METHYL-L-ALANINE N-[(9H-fluoren-9-ylmethoxy)carbonyl]-α-aminoisobutyric acid N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-AMINOISOBUTYRIC ACID N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-ALPHA-AMINOISOBUTYRIC ACID |
| CAS | 94744-50-0 |
| EINECS | 619-072-5 |
| InChI | InChI=1/C19H19NO4/c1-19(20,18(22)23)10-17(21)24-11-16-14-8-4-2-6-12(14)13-7-3-5-9-15(13)16/h2-9,16H,10-11,20H2,1H3,(H,22,23) |
| InChIKey | HOZZVEPRYYCBTO-UHFFFAOYSA-N |
FMoc-2-aMinoisobutyric acid FMoc-α-Methylalanine - Physico-chemical Properties
| Molecular Formula | C19H19NO4 |
| Molar Mass | 325.36 |
| Density | 1.256±0.06 g/cm3(Predicted) |
| Melting Point | 182-188°C |
| Boling Point | 544.3±33.0 °C(Predicted) |
| Appearance | White crystalline powder |
| Color | White to Almost white |
| BRN | 5604328 |
| pKa | 3.98±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | Moisture Sensitive |
| Refractive Index | 1.614 |
| MDL | MFCD00151913 |
FMoc-2-aMinoisobutyric acid FMoc-α-Methylalanine - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-21 |
| HS Code | 29242990 |
| Hazard Class | IRRITANT |
FMoc-2-aMinoisobutyric acid FMoc-α-Methylalanine - Reference Information
| Application | Fmoc-2-aminoisobutyric acid is a key intermediate for the preparation of enzalutamide. enzalutamide (enzalutamide,1) chemical name is 4-[3-(4-cyano-3-trifluoromethylphenyl)-5, 5-dimethyl-4-oxo-2-thio-imidazolidin-1-yl]-2-fluoro-n-methylbenzamide, it is a novel second-generation non-steroidal androgen receptor (AR) antagonist. The preparation process of Fmoc-2-aminoisobutyric acid is briefly described in this paper. |
| preparation | α-aminoisobutyric acid was added to a round-bottomed flask, 10% aqueous sodium carbonate solution was added, stirred and dissolved, and dioxane was added, the 10% dioxane solution of 9-fluorenylmethoxycarbonyl chloride is slowly added dropwise into the reaction solution in an ice bath. After the dropwise addition is completed, the reaction is carried out in an ice bath for 2 hours and then at room temperature for 8 hours, dilute with water, extract with diethyl ether 4 times, place the water layer in ice bath, adjust the pH value with concentrated hydrochloric acid to blue with Congo red test paper, and place it in refrigerator overnight, the resulting white precipitate was extracted with ethyl acetate, the combined organic liquids were washed with water, and the organic layer was dried over anhydrous magnesium sulfate to give the product Fmoc-2-aminoisobutyric acid. |
Last Update：2024-04-09 21:11:58
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View History
FMoc-2-aMinoisobutyric acid FMoc-α-Methylalanine
Formamide, N-[(6-oxo-2,4-cyclohexadien-1-ylidene)methyl]- (9CI)
Pentadecanal
4-乙基苯异硫氰酸酯
奥利司他相关化合物D
5-CHLOROINDOLE-2,3-DIONE
3-Piperidinepropanoic acid, 4-(4-morpholinyl)-1-(phenylmethyl)-, methyl ester
培氟沙星-D5
1-(丙基磺酰基)丙烷
2-仲丁基己酸
Formamide, N-[(6-oxo-2,4-cyclohexadien-1-ylidene)methyl]- (9CI)
Pentadecanal
4-乙基苯异硫氰酸酯
奥利司他相关化合物D
5-CHLOROINDOLE-2,3-DIONE
3-Piperidinepropanoic acid, 4-(4-morpholinyl)-1-(phenylmethyl)-, methyl ester
培氟沙星-D5
1-(丙基磺酰基)丙烷
2-仲丁基己酸